Organ System Disorders

Endocrine and Reproductive Disorders Practice Questions

20 free Endocrine and Reproductive Disorders practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Endocrine and Reproductive Disorders questions

20 questions
  1. Q1. A 12-year-old boy presents with polyuria, weight loss, and fatigue. Labs show hyperglycemia and low C-peptide levels. Which condition is most likely?
  2. Q2. A patient with type 2 diabetes has hyperosmolar hyperglycemic state (HHS). Which laboratory finding is expected?
  3. Q3. A patient presents with heat intolerance, palpitations, and tremor. Labs reveal low TSH and elevated T3/T4. What is the most likely diagnosis?
  4. Q4. A woman presents with irregular menses and hirsutism. Labs show elevated LH:FSH ratio. Which condition is most likely?
  5. Q5. A woman at 32 weeks gestation presents with hypertension and proteinuria. Which condition is suspected?
  6. Q6. A patient with hypothyroidism shows high TSH and low T3/T4. What is the most likely mechanism?
  7. Q7. A pregnant woman develops painless vaginal bleeding at 34 weeks. Ultrasound shows placenta covering the cervical os. Which condition is this?
  8. Q8. A patient with diabetes develops microalbuminuria. Which drug slows progression of diabetic nephropathy?
  9. Q9. A woman presents with galactorrhea and amenorrhea. Labs show elevated prolactin. What is the most likely cause?
  10. Q10. A patient with diabetic ketoacidosis presents with rapid deep breathing. What is this respiratory pattern called?
  11. Q11. A patient with hyperthyroidism undergoes radioactive iodine ablation. Which complication may occur?
  12. Q12. A sexually active woman presents with lower abdominal pain and cervical motion tenderness. What is the most likely diagnosis?
  13. Q13. A patient with hyperthyroidism has exophthalmos and pretibial myxedema. What is the underlying mechanism?
  14. Q14. A woman presents with infertility and dyspareunia. Ultrasound shows ectopic endometrial tissue. Which condition is this?
  15. Q15. A diabetic patient presents with numbness in both feet. What is the most likely mechanism?
  16. Q16. A patient with hypothyroidism shows periorbital edema. What causes this finding?
  17. Q17. A woman taking oral contraceptives presents with mild hypertension. What is a known effect of estrogen?
  18. Q18. A patient presents with fatigue, constipation, and cold intolerance. Labs reveal low T3/T4 and low TSH. Which condition is most likely?
  19. Q19. A pregnant woman develops painless vaginal bleeding and a 'snowstorm' pattern on ultrasound. Which condition is this?
  20. Q20. A patient with diabetes presents with retinopathy. What is the primary mechanism?