Endocrine and Reproductive Disorders · USMLE Step 1

A woman taking oral contraceptives presents with mild hypertension. What is a known effect of estrogen?

  1. Increased aldosterone production
  2. Decreased hepatic angiotensinogen
  3. Inhibition of renin release
  4. Reduced renal sodium retention
Show answer and explanation

Correct answer: Increased aldosterone production

Estrogen increases hepatic angiotensinogen production, activating the RAAS system and increasing blood pressure. This is a known side effect of OCPs.

Difficulty: Medium Question 17 of 20

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