Endocrine and Reproductive Disorders · USMLE Step 1

A 12-year-old boy presents with polyuria, weight loss, and fatigue. Labs show hyperglycemia and low C-peptide levels. Which condition is most likely?

  1. Type 2 diabetes mellitus
  2. Type 1 diabetes mellitus
  3. MODY2
  4. Secondary diabetes from glucocorticoid use
Show answer and explanation

Correct answer: Type 1 diabetes mellitus

Type 1 diabetes is characterized by autoimmune destruction of β-cells, leading to insulin deficiency and low C-peptide levels. It commonly presents in childhood.

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