Endocrine and Reproductive Disorders · USMLE Step 1

A patient with hypothyroidism shows periorbital edema. What causes this finding?

  1. Increased cortisol secretion
  2. Glycosaminoglycan accumulation
  3. Reduced plasma renin levels
  4. Increased aldosterone secretion
Show answer and explanation

Correct answer: Glycosaminoglycan accumulation

In hypothyroidism, mucopolysaccharide deposition causes nonpitting edema (myxedema). This commonly affects the face and eyelids.

Difficulty: Medium Question 16 of 20

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