Host immune response · USMLE Step 1

A patient with viral hepatitis develops hepatocyte apoptosis mediated by perforin and granzyme. Which cells are responsible?

  1. Plasma B cells
  2. CD8+ T cells
  3. Mast cells
  4. Macrophages
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Correct answer: CD8+ T cells

CD8+ cytotoxic T cells induce apoptosis via perforin/granzyme pathways. They target virus-infected hepatocytes.

Difficulty: Medium Question 17 of 20

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