Ultrastructure of cells · USMLE Step 1

Which ultrastructural feature would you expect to see in a cell that is highly active in secretion of glycosylated proteins (e.g., secretory epithelial cell)?

  1. A prominent nucleolus but sparse rough ER
  2. Expanded rough ER and Golgi with many vesicles
  3. A predominant abundance of lysosomes only
  4. Numerous peroxisomes with little surrounding cytosol
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Correct answer: Expanded rough ER and Golgi with many vesicles

Secretory cells typically have large amounts of rER for protein synthesis, a well-developed Golgi for post-translational modification (e.g., glycosylation) and many vesicles for secretion — features clearly visible on electron micrographs.

Difficulty: Medium Question 15 of 21

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