Ultrastructure of cells · USMLE Step 1

Which ultrastructural observation would most strongly suggest a cell is highly metabolically active and producing large amounts of ATP?

  1. Numerous prominent lysosomes
  2. Abundant mitochondria with cristae
  3. Few ribosomes and a small nucleus
  4. An expanded smooth ER network
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Correct answer: Abundant mitochondria with cristae

A high number of mitochondria with well-developed cristae under EM indicates robust capacity for oxidative phosphorylation and ATP generation, characteristic of metabolically active cells.

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