Stem Cells and Regeneration · USMLE Step 1

Which of the following best describes the concept of a stem cell “niche”?

  1. Any tissue where stem cells are actively dividing
  2. A specialized microenvironment regulating stem cell fate
  3. A laboratory dish used to culture stem cells in vitro
  4. An organ composed entirely of undifferentiated stem cells
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Correct answer: A specialized microenvironment regulating stem cell fate

A stem cell niche refers to the specialized microenvironment (extracellular matrix, supporting cells, signals) that maintains stem cells in an undifferentiated state or regulates their activation, self-renewal and differentiation.

Difficulty: Medium Question 7 of 20

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