Stem Cells and Regeneration · USMLE Step 1

Which of the following describes a major limitation of adult (somatic) stem cells compared to embryonic stem cells, in terms of potency?

  1. Adult stem cells generally divide much more slowly than others
  2. They are multipotent, not pluripotent, forming fewer cell types
  3. Adult stem cells are entirely unable to self-renew
  4. Adult stem cells always form tumors when transplanted
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Correct answer: They are multipotent, not pluripotent, forming fewer cell types

Adult stem cells are typically multipotent (or unipotent), so they can generate only certain related cell types rather than all body cell types, limiting their differentiation potential compared to pluripotent embryonic stem cells.

Difficulty: Medium Question 9 of 20

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