Stem Cells and Regeneration · USMLE Step 1

What is the main advantage of using Induced pluripotent stem cells (iPSCs) in regenerative medicine compared to embryonic stem cells?

  1. They are totipotent rather than merely pluripotent.
  2. They come from adult cells, avoiding ethical concerns.
  3. They do not require specialized culture conditions.
  4. They cannot differentiate, reducing risk of tumors.
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Correct answer: They come from adult cells, avoiding ethical concerns.

iPSCs are generated by reprogramming adult somatic cells, avoiding use of embryos — thus bypassing many ethical issues associated with embryonic stem cells while retaining pluripotent properties.

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