Stem Cells and Regeneration · USMLE Step 1

In the context of regeneration, what is the meaning of the term “plasticity” with respect to adult stem cells?

  1. Permanent quiescence of all resident stem cells
  2. Complete inability of adult stem cells to differentiate at all
  3. Gaining broader differentiation potential in some conditions
  4. A fixed output of only one specific cell type
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Correct answer: Gaining broader differentiation potential in some conditions

Plasticity refers to the capacity of some adult stem cells to widen their differentiation potential (beyond their usual lineage) under certain environmental or experimental conditions, which may aid in tissue repair.

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