Stem Cells and Regeneration · USMLE Step 1

Which of the following correctly ranks stem cell potency from most to least potent?

  1. Unipotent > Multipotent > Pluripotent > Totipotent
  2. Totipotent > Pluripotent > Multipotent > Unipotent
  3. Multipotent > Totipotent > Pluripotent > Unipotent
  4. Pluripotent > Totipotent > Multipotent > Unipotent
Show answer and explanation

Correct answer: Totipotent > Pluripotent > Multipotent > Unipotent

Totipotent cells (e.g. zygote) can form all cell types including extra-embryonic tissues; pluripotent cells can form nearly all body cell types; multipotent cells generate a restricted lineage; unipotent cells only one cell type — so potency decreases in that order.

Difficulty: Medium Question 18 of 20

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