Stem Cells and Regeneration · USMLE Step 1

Which of the following scenarios exemplifies regeneration by stem cell activation rather than repair by scar (fibrosis)?

  1. Formation of granulation tissue and collagen deposition after myocardial infarction
  2. Renewal of intestinal epithelium via intestinal stem cells after mucosal injury
  3. Formation of nonfunctional fibrous tissue replacing lost tissue in severe liver damage
  4. Permanent scar formation in skeletal muscle after trauma
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Correct answer: Renewal of intestinal epithelium via intestinal stem cells after mucosal injury

The intestinal epithelium regenerates via activation of resident intestinal stem cells to replace damaged mucosal cells, restoring normal structure and function — a true regenerative process rather than fibrotic scar formation. Adult stem cells in tissues with high turnover mediate this.

Difficulty: Medium Question 17 of 20

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