Cell-cell junctions · USMLE Step 1

Which of the following statements accurately distinguishes between adherens junctions and tight junctions in epithelial cells?

  1. Tight junctions connect actin cytoskeletons; adherens junctions form a paracellular seal.
  2. Adherens junctions give actin-based adhesion; tight junctions seal against paracellular passage.
  3. Both junction types anchor intermediate filaments firmly between neighboring cells.
  4. Only tight junctions permit direct intercellular diffusion of small molecules.
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Correct answer: Adherens junctions give actin-based adhesion; tight junctions seal against paracellular passage.

Adherens junctions provide mechanical adhesion between cells via actin-cytoskeleton linking, while tight junctions act as occluding junctions that seal adjacent cell membranes to prevent paracellular flow.

Difficulty: Medium Question 13 of 20

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