Cell-cell junctions · USMLE Step 1

Which family of proteins mediates calcium-dependent adhesion at adherens junctions and desmosomes?

  1. Connexins
  2. Claudins
  3. Cadherins
  4. Integrins
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Correct answer: Cadherins

Cadherins are transmembrane adhesion molecules that mediate calcium-dependent cell–cell adhesion at adherens junctions and desmosomes, linking adjacent cells mechanically through cytoskeletal attachments.

Difficulty: Medium Question 12 of 20

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