Which metabolite can activate PFK-1 even in the presence of high ATP, thereby promoting glycolysis?
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Correct answer: Fructose-2,6-bisphosphate
Fructose-2,6-bisphosphate is a potent allosteric activator of PFK-1; it increases the enzyme’s affinity for its substrate and diminishes the inhibitory effect of ATP, thus promoting glycolysis under conditions such as after a meal.
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