Screening and Diagnostic Test Validity · USMLE Step 1

A study shows that a test has high NPV in a population. What is the most likely explanation?

  1. High prevalence of disease
  2. Low prevalence of disease
  3. Low specificity
  4. High false-positive rate
Show answer and explanation

Correct answer: Low prevalence of disease

Negative predictive value (NPV) increases when disease prevalence is low. A negative result is more likely to be a true negative in such populations.

Difficulty: Medium Question 10 of 20

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