Liver and Pancreas Functions · Physiology

Which enzyme in the liver is responsible for the conjugation of bilirubin with glucuronic acid to make it water-soluble?

  1. Heme oxygenase enzyme complex
  2. UDP-glucuronosyltransferase
  3. Biliverdin reductase enzyme
  4. Cytochrome P450 monooxygenase
Show answer and explanation

Correct answer: UDP-glucuronosyltransferase

UGT converts unconjugated bilirubin into conjugated bilirubin by adding glucuronic acid molecules. This process is essential for making bilirubin water-soluble so it can be excreted into the bile.

Difficulty: Medium Question 21 of 40

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