Liver and Pancreas Functions · Physiology

During prolonged fasting, the liver maintains blood glucose levels through gluconeogenesis. Which of the following is a primary substrate used by the liver for this process?

  1. Glycogen from the liver
  2. Acetyl-CoA from beta-oxidation
  3. Amino acids such as alanine
  4. Fatty acids from adipose tissue
Show answer and explanation

Correct answer: Amino acids such as alanine

Gluconeogenesis is the synthesis of glucose from non-carbohydrate sources like lactate, glycerol, and glucogenic amino acids. While glycogen provides glucose via glycogenolysis, it is not a substrate for gluconeogenesis itself.

Difficulty: Medium Question 26 of 40

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