Which enzyme, located on the brush border of the small intestine, is the essential 'trigger' for activating the pancreatic proteolytic cascade?
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Correct answer: Enteropeptidase (enterokinase)
Enteropeptidase converts inactive trypsinogen into active trypsin. Once trypsin is formed, it autocatalytically activates more trypsinogen and other proenzymes like chymotrypsinogen and procarboxypeptidase.
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