In pancreatic ductal cells, the apical transport of bicarbonate into the lumen is most closely linked to the exchange of which ion?
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Correct answer: Chloride (Cl-)
Bicarbonate is secreted into the pancreatic duct lumen via a Cl-/HCO3- exchanger. The recycle of chloride through the CFTR channel is necessary to maintain the gradient required for continued bicarbonate secretion.
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