Absorption mechanisms · Physiology

Oral rehydration therapy (ORT) is highly effective for treating secretory diarrhea because it exploits which physiological principle?

  1. The inhibition of chloride secretion by high luminal glucose concentrations
  2. Coupled sodium-glucose absorption creating an osmotic gradient for water
  3. The direct stimulation of the Na+/K+ ATPase pump by luminal potassium
  4. The ability of fructose to bypass the damaged SGLT1 glucose transporters
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Correct answer: Coupled sodium-glucose absorption creating an osmotic gradient for water

In many diarrheal diseases, the SGLT1 transporter remains functional. Providing both sodium and glucose ensures their co-transport into enterocytes, which draws water back into the body via osmosis, even when other secretory mechanisms are overactive.

Difficulty: Medium Question 26 of 40

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