Absorption mechanisms · Physiology

In the colon, short-chain fatty acids (SCFAs) like butyrate are produced by bacterial fermentation. How are they primarily absorbed?

  1. Active transport via the SGLT1 glucose carrier protein
  2. Exchange with bicarbonate or via H+-coupled transporters
  3. Passive diffusion into the lymphatic lacteals of the villi
  4. They are not absorbed at all and are excreted in the feces
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Correct answer: Exchange with bicarbonate or via H+-coupled transporters

SCFAs are a vital energy source for colonocytes. They are absorbed via sodium-linked transporters or $H^+$-coupled monocarboxylate transporters (MCTs), often in exchange for bicarbonate.

Difficulty: Medium Question 33 of 40

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