Absorption mechanisms · Physiology

Which of the following describes the correct path of a glucose molecule from the intestinal lumen to the blood?

  1. SGLT1 (apical) $\rightarrow$ Cytosol $\rightarrow$ GLUT2 (basolateral)
  2. GLUT5 (apical) $\rightarrow$ Cytosol $\rightarrow$ SGLT1 (basolateral)
  3. Simple diffusion $\rightarrow$ Cytosol $\rightarrow$ Na+/K+ ATPase (basolateral)
  4. SGLT1 (apical) $\rightarrow$ Cytosol $\rightarrow$ SGLT1 (basolateral)
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Correct answer: SGLT1 (apical) $\rightarrow$ Cytosol $\rightarrow$ GLUT2 (basolateral)

Glucose enters the cell through SGLT1 on the apical membrane using the sodium gradient. It then exits the cell into the interstitial fluid and portal blood through GLUT2 on the basolateral membrane via facilitated diffusion.

Difficulty: Medium Question 35 of 40

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