Frequent use of Beta-2 agonists can lead to a reduced clinical response over time. This phenomenon is known as:
Show answer and explanation
Correct answer: Tachyphylaxis (Downregulation)
Tachyphylaxis occurs when continuous stimulation of receptors leads to their internalization and degradation (downregulation). This reduces the number of available receptors on the cell surface, decreasing the drug's efficacy.
Keep practicing
More Beta-2 Agonists questions
- Which of the following is a potential cardiac side effect of Beta-2 agonists, especially at high doses?
- In the context of G-protein signaling, which enzyme is responsible for the degradation of cAMP, the second messenger for Beta-2 agonists?
- Vilanterol is currently available in the United States only in which formulation?
- Why is the use of non-selective beta-blockers (like Propranolol) contraindicated in patients using Beta-2 agonists for asthma?
- Which Beta-2 agonist is available in an oral form, though it is rarely used due to increased systemic side effects?
- How do Beta-2 agonists affect the release of inflammatory mediators from mast cells?