In the context of G-protein signaling, which enzyme is responsible for the degradation of cAMP, the second messenger for Beta-2 agonists?
Show answer and explanation
Correct answer: Phosphodiesterase
Phosphodiesterase enzymes break down cAMP into 5'-AMP, terminating the signaling cascade. Inhibiting this enzyme (as methylxanthines do) can prolong the bronchodilatory effects initiated by Beta-2 agonists.
Keep practicing
More Beta-2 Agonists questions
- Vilanterol is currently available in the United States only in which formulation?
- Why is the use of non-selective beta-blockers (like Propranolol) contraindicated in patients using Beta-2 agonists for asthma?
- Which Beta-2 agonist is available in an oral form, though it is rarely used due to increased systemic side effects?
- How do Beta-2 agonists affect the release of inflammatory mediators from mast cells?
- Which molecular structure is a common feature of the 'catecholamine' type Beta-agonists that makes them susceptible to COMT degradation?
- Which statement best describes the use of Beta-2 agonists in the management of COPD compared to asthma?