Metolazone is unique among thiazide-type diuretics because it:
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Correct answer: Retains efficacy in patients with impaired renal function
Most thiazides lose efficacy when GFR is low, but metolazone remains effective in patients with advanced renal insufficiency. It is often used in combination with loop diuretics to overcome diuretic resistance.
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More Thiazide Diuretics questions
- Which pH disturbance is typically associated with the use of thiazide diuretics?
- In the context of bone health, thiazides are associated with which of the following?
- Which of the following is the most appropriate initial management for a patient on thiazide therapy who develops symptomatic hypokalemia?
- What is the primary molecular target inhibited by thiazide diuretics in the nephron?
- In which segment of the renal tubule do thiazide diuretics exert their primary effect?
- Which of the following electrolyte changes is a characteristic side effect of thiazide diuretics, distinguishing them from loop diuretics?