What is the primary molecular target inhibited by thiazide diuretics in the nephron?
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Correct answer: Na+/Cl- symporter (NCC)
Thiazide diuretics work by binding to the chloride site of the Na+/Cl- symporter (NCC) in the early distal convoluted tubule. This leads to increased urinary excretion of sodium and chloride.
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More Thiazide Diuretics questions
- In which segment of the renal tubule do thiazide diuretics exert their primary effect?
- Which of the following electrolyte changes is a characteristic side effect of thiazide diuretics, distinguishing them from loop diuretics?
- Why are thiazide diuretics considered less effective in patients with a Glomerular Filtration Rate (GFR) below 30 mL/min?
- Which of the following drugs is a 'thiazide-like' diuretic with a significantly longer half-life than Hydrochlorothiazide?
- Thiazide diuretics can lead to which of the following metabolic disturbances?
- How do thiazide diuretics affect glucose metabolism?