Thiazide Diuretics · Pharmacology

Which of the following is the most appropriate initial management for a patient on thiazide therapy who develops symptomatic hypokalemia?

  1. Switch the patient to a loop diuretic
  2. Add an ACE inhibitor or potassium supplement
  3. Discontinue the thiazide and start a beta-blocker
  4. Restrict dietary potassium and salt intake
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Correct answer: Add an ACE inhibitor or potassium supplement

Hypokalemia is common with thiazides. Adding a potassium-sparing diuretic, an ACE inhibitor, or a potassium supplement is the standard approach to maintain therapeutic levels and prevent arrhythmias.

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