Thiazide Diuretics · Pharmacology

In the context of bone health, thiazides are associated with which of the following?

Increased risk of hip and vertebral fractures
Reduced risk of osteoporosis-related fractures
No measurable effect on bone mineral density
Direct inhibition of osteoblast activity and bone formation

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Correct answer: Reduced risk of osteoporosis-related fractures

By promoting calcium reabsorption and decreasing urinary calcium loss, thiazides have been shown to maintain bone mineral density and reduce the risk of fractures in elderly patients.

Difficulty: Medium Question 19 of 20

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Which of the following is the most appropriate initial management for a patient on thiazide therapy who develops symptomatic hypokalemia?
What is the primary molecular target inhibited by thiazide diuretics in the nephron?
In which segment of the renal tubule do thiazide diuretics exert their primary effect?
Which of the following electrolyte changes is a characteristic side effect of thiazide diuretics, distinguishing them from loop diuretics?
Why are thiazide diuretics considered less effective in patients with a Glomerular Filtration Rate (GFR) below 30 mL/min?
Which of the following drugs is a 'thiazide-like' diuretic with a significantly longer half-life than Hydrochlorothiazide?