Which pharmacological strategy can reduce the impact of the first-pass effect?
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Correct answer: Using sublingual or transdermal routes
Routes such as sublingual or transdermal administration allow drugs to enter systemic circulation directly. This avoids metabolism in the liver before the drug becomes active.
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More First-Pass Effect questions
- Which physiological factor influences the extent of the first-pass effect?
- Which statement best summarizes the clinical significance of the first-pass effect?
- What is meant by the first-pass effect in pharmacology?
- Which organ is primarily responsible for the first-pass metabolism of drugs?
- Which route of drug administration is most affected by the first-pass effect?
- Which route of administration bypasses the first-pass metabolism completely?