Which physiological factor influences the extent of the first-pass effect?
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Correct answer: Hepatic blood flow
Hepatic blood flow determines how much drug reaches the liver and how quickly it is metabolized. Increased blood flow can increase exposure to hepatic enzymes.
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More First-Pass Effect questions
- Which statement best summarizes the clinical significance of the first-pass effect?
- What is meant by the first-pass effect in pharmacology?
- Which organ is primarily responsible for the first-pass metabolism of drugs?
- Which route of drug administration is most affected by the first-pass effect?
- Which route of administration bypasses the first-pass metabolism completely?
- Which drug property is most likely to be affected by a strong first-pass effect?