Which type of drug is most affected by the first-pass effect?
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Correct answer: Drugs absorbed from the intestinal tract
Drugs absorbed from the gastrointestinal tract enter the portal circulation and pass through the liver before reaching systemic circulation. This makes them susceptible to the first-pass effect.
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More First-Pass Effect questions
- Which pharmacological strategy can reduce the impact of the first-pass effect?
- Which physiological factor influences the extent of the first-pass effect?
- Which statement best summarizes the clinical significance of the first-pass effect?
- What is meant by the first-pass effect in pharmacology?
- Which organ is primarily responsible for the first-pass metabolism of drugs?
- Which route of drug administration is most affected by the first-pass effect?