The use of Probenecid to prolong the half-life of Penicillin is based on which mechanism?
Show answer and explanation
Correct answer: Competitive inhibition of tubular secretion
Probenecid competes with Penicillin for the organic anion transporters (OAT) in the proximal tubule. By blocking the secretion of Penicillin into the tubular lumen, Probenecid decreases its renal excretion and extends its duration of action.
Keep practicing
More Drug Excretion questions
- What is the clinical significance of 'Enterohepatic Recirculation' in drug excretion?
- Which factor most significantly determines the 'Renal Clearance' of a drug?
- Volatile anesthetics, such as Halothane, are primarily excreted through which route?
- What happens to the renal excretion of a basic drug, such as Amphetamine, when the urine is acidified with Ammonium Chloride?
- Which of the following describes 'Zero-Order Elimination' kinetics?
- A drug with a high molecular weight (>300-500 Daltons) and a strong polar group is most likely to be excreted through which pathway?