Which renal process is responsible for the 'clearance' of drugs like Penicillin, which can exceed the normal glomerular filtration rate (GFR)?
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Correct answer: Active tubular secretion
Active tubular secretion occurs in the proximal tubule via specific carrier systems (OATs and OCTs). This energy-dependent process can strip drugs even from plasma proteins, allowing for a clearance rate higher than the GFR.
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