Which factor most significantly determines the 'Renal Clearance' of a drug?
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Correct answer: The rate of filtration, secretion, and reabsorption in the nephron
Renal clearance is the net result of three processes: (Filtration + Secretion) minus Reabsorption. A drug that is filtered and secreted but not reabsorbed will have a very high renal clearance.
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