What happens to the renal excretion of a basic drug, such as Amphetamine, when the urine is acidified with Ammonium Chloride?
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Correct answer: Excretion increases as the drug becomes ionized and trapped in the tubule
Acidifying the urine causes basic drugs to become protonated (ionized). This reduces their lipid solubility and prevents them from diffusing back into the bloodstream, thereby accelerating their elimination.
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