A drug with a high molecular weight (>300-500 Daltons) and a strong polar group is most likely to be excreted through which pathway?
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Correct answer: Biliary excretion into the gut
Large, polar molecules that are not easily filtered by the kidney or those that are actively transported by hepatocytes are often excreted into the bile. These substances are then eliminated in the feces unless they undergo enterohepatic recycling.
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