PPI use should be carefully monitored in patients with liver cirrhosis because:
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Correct answer: The half-life of the drug may be significantly prolonged
Since PPIs are primarily metabolized by the liver, advanced liver disease can significantly decrease clearance. While dose adjustments aren't always required for short-term use, long-term use in cirrhotic patients should be cautious.
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More Proton Pump Inhibitors questions
- Which of the following enzymes is the direct target of Proton Pump Inhibitors (PPIs)?
- PPIs are administered as inactive prodrugs. In which environment are they converted to their active sulfenamide form?
- What type of chemical bond do PPIs form with the cysteine residues of the H+/K+ ATPase pump?
- To ensure maximal efficacy, when should a delayed-release oral PPI typically be administered?
- Which of the following PPIs is the S-enantiomer of Omeprazole and typically exhibits slower hepatic clearance?
- Long-term use of PPIs has been associated with an increased risk of which gastrointestinal infection?