PPIs are administered as inactive prodrugs. In which environment are they converted to their active sulfenamide form?
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Correct answer: The acidic environment of the parietal cell canaliculi
PPIs are lipophilic weak bases that accumulate in the acidic canaliculi of parietal cells. There, they undergo proton-catalyzed conversion to a reactive thiophilic sulfenamide that binds to the proton pump.
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