Which of the following enzymes is the direct target of Proton Pump Inhibitors (PPIs)?
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Correct answer: H+/K+ ATPase
PPIs target the H+/K+ ATPase enzyme system, also known as the proton pump, located on the apical membrane of the gastric parietal cell. This enzyme is the final common pathway for gastric acid secretion.
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More Proton Pump Inhibitors questions
- PPIs are administered as inactive prodrugs. In which environment are they converted to their active sulfenamide form?
- What type of chemical bond do PPIs form with the cysteine residues of the H+/K+ ATPase pump?
- To ensure maximal efficacy, when should a delayed-release oral PPI typically be administered?
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