A patient with Gastroesophageal Reflux Disease (GERD) fails to respond to once-daily PPI. What is the most common next step in pharmacological management?
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Correct answer: Increasing the dose to twice daily (before breakfast and dinner)
For patients with refractory GERD, doubling the PPI dose by adding a second dose before the evening meal is a standard clinical step to achieve better nocturnal acid control and daytime suppression.
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