A patient is taking Cimetidine along with Warfarin. What is the most likely outcome for the patient's INR?
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Correct answer: The INR will rise, increasing bleeding risk
Cimetidine inhibits the metabolism of S-warfarin (the more potent isomer) via CYP2C9. This leads to higher warfarin levels and an elevated INR, putting the patient at risk for bleeding.
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