Which of the following describes the 'acid rebound' phenomenon associated with H2RAs?
Show answer and explanation
Correct answer: A surge in acid secretion when therapy is stopped
Similar to PPIs, chronic H2RA use can lead to hypergastrinemia as the body tries to compensate for the higher pH. Upon discontinuation, this excess gastrin can cause a temporary spike in acid production.
Keep practicing
More H2 Blockers questions
- H2 blockers are frequently used in hospitalized patients primarily to prevent which condition?
- What is the primary mechanism of action of H2-receptor antagonists (H2RAs)?
- Which of the following H2 blockers is well known for inhibiting multiple Cytochrome P450 (CYP) enzymes, leading to many drug interactions?
- Which H2 blocker is associated with anti-androgenic side effects, such as gynecomastia and impotence in men?
- Compared to Proton Pump Inhibitors (PPIs), H2 blockers are generally considered:
- A patient develops 'tachyphylaxis' within 2–6 days of starting an H2 blocker. What does this term imply in this context?