The SLCO1B1 gene encodes a transporter protein that facilitates the hepatic uptake of which drug class?
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Correct answer: Statins
SLCO1B1 encodes the OATP1B1 transporter. Genetic variants that decrease the function of this transporter (like the *5 allele) lead to increased plasma concentrations of statins, particularly simvastatin, significantly increasing the risk of myopathy.
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