Which sedative-hypnotic is highly selective for the alpha-1 (BZ1) subunit of the GABA-A receptor, primarily providing hypnotic effects with minimal muscle relaxation?
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Correct answer: Zolpidem
Zolpidem belongs to the non-benzodiazepine class (Z-drugs) and preferentially binds to the BZ1 (alpha-1) receptor subtype. This selectivity provides effective sleep induction with less interference on muscle coordination or anxiety compared to non-selective benzodiazepines.
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