Which benzodiazepine is preferred for use in elderly patients or those with liver failure because it undergoes only Phase II conjugation?
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Correct answer: Lorazepam
The 'LOT' drugs (Lorazepam, Oxazepam, and Temazepam) do not require Phase I oxidative metabolism by CYP450 enzymes. Because they are directly conjugated (Phase II), they do not form active metabolites and are safer in patients with reduced hepatic function.
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