Which of the following metabolites of Morphine is pharmacologically active and may accumulate in patients with renal failure, leading to toxicity?
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Correct answer: Morphine-6-glucuronide
Morphine is conjugated in the liver to M3G and M6G. While M3G may cause neurotoxicity (seizures), M6G is a more potent analgesic than morphine itself and is excreted by the kidneys, making it dangerous in patients with renal impairment.
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