Opioids · Pharmacology

Buprenorphine is unique in the treatment of opioid use disorder because it acts as a:

  1. Full Mu-receptor agonist
  2. Partial Mu-receptor agonist
  3. Selective Kappa-receptor antagonist
  4. Non-competitive NMDA antagonist
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Correct answer: Partial Mu-receptor agonist

As a partial agonist, buprenorphine has a 'ceiling effect' on respiratory depression, making it safer than full agonists. It also has a very high affinity for the Mu receptor, which allows it to block the effects of other opioids if they are used concurrently.

Difficulty: Medium Question 6 of 20

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