Opioids · Pharmacology

Methadone is used in detoxification programs primarily because it:

  1. Is an antagonist that blocks the euphoric 'high'
  2. Has a very short half-life that allows rapid clearance between doses
  3. Is a long-acting full agonist that prevents withdrawal and cravings
  4. Does not cross the blood-brain barrier
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Correct answer: Is a long-acting full agonist that prevents withdrawal and cravings

Methadone's long half-life (over 24 hours) provides steady plasma levels, avoiding the 'highs and lows' associated with shorter-acting opioids like heroin. This stability helps patients maintain normal daily functioning while preventing withdrawal.

Difficulty: Medium Question 9 of 20

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